Human infants are commonly exposed to and treated with antibiotics during the birthing process. However, in nonhuman primates may change the way doctors approach antibiotic treatment. A study conducted by the (CCHMC) and the (CNPRC) provides the first clear evidence in nonhuman primates that early-life antibiotic treatment can affect the gut microbiome, altering the immune system鈥檚 response to lung infections. The work was published June 15 in Science Translational Medicine.
Gut microbiota plays a vital role in how a person fights disease, digests food, and even their mood and psychological processes. It also promotes balance between pathways driving tissue repair and inflammatory responses associated with clinical recovery from infection in infants.
鈥淲e found that early-life antibiotic use had consequences not only disrupting the microbiota of the infant macaques but also affected the ways in which they responded to infection during the critical first month of life,鈥 said Hitesh Deshmukh, attending CCHMC neonatologist and senior author of the study.
Deshmukh and colleagues analyzed data from infant rhesus macaques housed at the CNPRC. The macaques were given the same antibiotics used in human infants and then challenged with a respiratory pathogen similar to pneumonia. The macaques received the same round-the-clock care and treatment used in a human neonatal intensive care unit.
Compared to a control group, rhesus macaque infants that received a week of antibiotic treatments exhibited a reduction in the diversity of microbial species in their gut and delayed development of their intestinal microbiota. Rhesus infants that received antibiotics showed more clinically severe pneumonia cases than the control group. The authors also observed changes in the genetic expression and functionality of immune cells in the bloodstream.
Antibiotics protect infants from contracting an infection during vaginal birth or secondhand during cesarean delivery.
鈥淲e give those antibiotics for a reason; we can鈥檛 stop giving antibiotics鈥ut we also have to recognize that these antibiotics cause a change in the babies鈥 [immune] response,鈥 said Deshmukh.
Genes predict susceptibility to pneumonia
Using advanced technologies, researchers identified a type of genetic signature in these infants resulting from the antibiotic treatment which predicts susceptibility to pneumonia.
鈥淧erhaps in the future, we would use this gene signature as a quick, easy science-based test to screen babies and鈥hen the doctors could be more aggressive in treating pneumonia because they would know [which] babies were at risk鈥, said Jake Stevens, first author of the study.
Now that researchers have a detailed description of how early-life antibiotic treatment changes the immune system, they will move into other animal models like mice to investigate the mechanistic causes and underlying molecular biology of those changes.
鈥淭his is the first step in understanding the specific changes that are happening in a more clinically relevant way so that we can give back the things that are being disrupted to help these babies get the benefits of antibiotics but avoid some of the risks,鈥 said Stevens.
鈥嬧婣dditional authors on this study are: at 澳门六合彩资料库 Davis, Lisa Miller, Dennis Hartigan O鈥機onnor; at Cincinnati Children鈥檚 Hospital Medical Center, Shelby Steinmeyer, Madeline Bonfield, Laura Peterson, Gary Jerilyn, Ian Lewkowich, Yan Xu, Yina Du, Minzhe Guo, Timothy Wang, William Zacharias, Nathan Salomonis and Claire Chougnet; and James L. Wynn University of Florida, College of Medicine.
Media Resources
(Science Translational Medicine)